Zymes results in the intralysosomal accumulation Grossly reduced activity of mutated lysosomal en. The hyaluronan is an exceptionįailure of degradation because of absent or Stance of connective tissue, of nuclear and cell Teoglycans, major constituents of the ground sub. Synthesized and linked to proteins to form pro. The major glycosaminogly-cans are chondroitin-4-sulfate, chondroitin-6-sul-fate, heparin sulfate, dermatan sulfate, keratin sulfate, and hyaluronan. Quasimodo had as well Mucopolysaccharidoses which are hereditary, pro-gressive diseases caused by mutations of genes coding for lysosomal enzymes needed to degrade glycosaminoglycans. The overgrowth is usually asymmetric, which means it affects the right and left sides of the body differently. Organs and tissues affected by the disease grow out of proportion to the rest of the body. However, that is not it, Quasimodo was suffering as well from what is known the Proteus syndrome which is is a rare condition characterized by overgrowth of the bones, skin, and other tissues. Kyphosis is a spinal disorder in which an excessive outward curve of the spine results in an abnormal rounding of the upper back. All of us have watched the hunchback of Notre Dame, however after finishing my medical degree i got so curious to know what Quasimodo was suffering from, and after doing several research it was found that he was suffering from spinal cord deformities know as kyphosis.

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